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a tTA protein of the invention has at least one amino acid mutation within the tetracycline binding domain? The isolated nucleic acid of claim 1, 2, or 3, wherein the encoded modified tetracycline repressor binds to a tetracycline operator sequence in a prokaryotic organism with a greater affinity in the presence of tetracycline or a tetracycline analog than in the absence of tetracycline or the tetracycline analog with a greater affinity at 28° C. However, undeservingly cost of sarafem
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